Fabrication and evaluation of 3D printed PLGA/nHA/GO scaffold for bone tissue engineering

Fabrication and evaluation of 3D printed PLGA/nHA/GO scaffold for bone tissue engineering

Blog Article

Abstract The study aimed to fabricate and evaluate a Pull Through Knife Sharpeners bone tissue engineering scaffold made from a composite of polylactic-co-glycolic acid (PLGA), nano-hydroxyapatite (nHA), and graphene oxide (GO) using low-temperature 3D printing and freeze-drying techniques.The scaffolds were produced with varying compositions: PLGA alone and in combination with nHA and GO.The macro and microstructure, pore size, porosity, mechanical properties, and in vitro biocompatibility were assessed.Bone marrow mesenchymal stem cells (BMSCs) were co-cultured with the scaffolds to evaluate cell adhesion, proliferation, and cytotoxicity.The PLGA/nHA/GO composite scaffolds exhibited optimal pore size and microtopography, enhanced mechanical properties, excellent water absorption, and appropriate degradability.

The co-culture with BMSCs demonstrated improved cell adhesion and proliferation, indicating good biocompatibility.The PLGA/nHA/GO composite scaffolds show potential as a bone tissue engineering Vacuum Pipe material due to their favorable properties and biocompatibility, suggesting their suitability for bone defect repair applications.